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Baeyer-Villiger oxidation

Last updated

Jan 23, 2023
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- Appel Reaction
- Bartoli indole synthesis

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Baeyer-Villiger oxidation is the oxidation of a ketone to a carboxylic acid ester using a peroxyacid as the oxidizing agent. eg. 1:

eg. 2:

Mechanism

When the two ligands on the carbonyl carbon in the ketone are different, Baeyer-Villiger oxidation is regioselective. Of the two alpha carbons in the ketone, the one that can stabilize a positive charge more effectively, which is the more highly substituted one, migrates from carbon to oxygen preferentially.

eg. 1:

eg. 2:

References

- Gamini Gunawardena from the OChemPal site (Utah Valley University)

Mechanism

References

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