Section 3 Final Evaluation
- Page ID
- 309465
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\(\newcommand{\avec}{\mathbf a}\) \(\newcommand{\bvec}{\mathbf b}\) \(\newcommand{\cvec}{\mathbf c}\) \(\newcommand{\dvec}{\mathbf d}\) \(\newcommand{\dtil}{\widetilde{\mathbf d}}\) \(\newcommand{\evec}{\mathbf e}\) \(\newcommand{\fvec}{\mathbf f}\) \(\newcommand{\nvec}{\mathbf n}\) \(\newcommand{\pvec}{\mathbf p}\) \(\newcommand{\qvec}{\mathbf q}\) \(\newcommand{\svec}{\mathbf s}\) \(\newcommand{\tvec}{\mathbf t}\) \(\newcommand{\uvec}{\mathbf u}\) \(\newcommand{\vvec}{\mathbf v}\) \(\newcommand{\wvec}{\mathbf w}\) \(\newcommand{\xvec}{\mathbf x}\) \(\newcommand{\yvec}{\mathbf y}\) \(\newcommand{\zvec}{\mathbf z}\) \(\newcommand{\rvec}{\mathbf r}\) \(\newcommand{\mvec}{\mathbf m}\) \(\newcommand{\zerovec}{\mathbf 0}\) \(\newcommand{\onevec}{\mathbf 1}\) \(\newcommand{\real}{\mathbb R}\) \(\newcommand{\twovec}[2]{\left[\begin{array}{r}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\ctwovec}[2]{\left[\begin{array}{c}#1 \\ #2 \end{array}\right]}\) \(\newcommand{\threevec}[3]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\cthreevec}[3]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \end{array}\right]}\) \(\newcommand{\fourvec}[4]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\cfourvec}[4]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \end{array}\right]}\) \(\newcommand{\fivevec}[5]{\left[\begin{array}{r}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\cfivevec}[5]{\left[\begin{array}{c}#1 \\ #2 \\ #3 \\ #4 \\ #5 \\ \end{array}\right]}\) \(\newcommand{\mattwo}[4]{\left[\begin{array}{rr}#1 \amp #2 \\ #3 \amp #4 \\ \end{array}\right]}\) \(\newcommand{\laspan}[1]{\text{Span}\{#1\}}\) \(\newcommand{\bcal}{\cal B}\) \(\newcommand{\ccal}{\cal C}\) \(\newcommand{\scal}{\cal S}\) \(\newcommand{\wcal}{\cal W}\) \(\newcommand{\ecal}{\cal E}\) \(\newcommand{\coords}[2]{\left\{#1\right\}_{#2}}\) \(\newcommand{\gray}[1]{\color{gray}{#1}}\) \(\newcommand{\lgray}[1]{\color{lightgray}{#1}}\) \(\newcommand{\rank}{\operatorname{rank}}\) \(\newcommand{\row}{\text{Row}}\) \(\newcommand{\col}{\text{Col}}\) \(\renewcommand{\row}{\text{Row}}\) \(\newcommand{\nul}{\text{Nul}}\) \(\newcommand{\var}{\text{Var}}\) \(\newcommand{\corr}{\text{corr}}\) \(\newcommand{\len}[1]{\left|#1\right|}\) \(\newcommand{\bbar}{\overline{\bvec}}\) \(\newcommand{\bhat}{\widehat{\bvec}}\) \(\newcommand{\bperp}{\bvec^\perp}\) \(\newcommand{\xhat}{\widehat{\xvec}}\) \(\newcommand{\vhat}{\widehat{\vvec}}\) \(\newcommand{\uhat}{\widehat{\uvec}}\) \(\newcommand{\what}{\widehat{\wvec}}\) \(\newcommand{\Sighat}{\widehat{\Sigma}}\) \(\newcommand{\lt}{<}\) \(\newcommand{\gt}{>}\) \(\newcommand{\amp}{&}\) \(\definecolor{fillinmathshade}{gray}{0.9}\)1. _______ is a method used in analyzing base substitution mutation resulting from single nucleotide polymorphism.
Micronucleus assay
Chromosome aberration study
Allele-Specific PCR
Chromatography
- Answer
-
Allele-Specific PCR
2. Proteomic assay analyzes the effect of toxicants in cellular toxicity signaling pathways or mechanisms through:
Immunofluorescence
Immunoblot
Immunoprecipitation
All of the above
- Answer
-
All of the above
3. In Ladder Assay, fragmented DNA can be separated by agarose gel electrophoresis and can be visualized as “ladder” by __________ staining.
Ethidium bromide
Eosin
Gram
Wright’s
- Answer
-
Ethidium bromide
4. Trisomy is a form of aneuploidy interpreted as:
Single missing chromosome from diploid set.
Three copies of a single chromosome from a diploid set
Three copies of a single chromosome from a triploid set
Single missing chromosome from a triploid set
- Answer
-
Three copies of a single chromosome from a diploid set
5. Gene mutations in which a single base nucleotide is replaced by another nucleotide are known as:
Frame shift
Quantitative change in nucleotide
Qualitative change in nucleotide
Left shift
- Answer
-
Qualitative change in nucleotide
6. Some structural chromosomal aberrations caused by genotoxic chemicals in cytogenetic assays of mammalian cells include the following EXCEPT:
Dicentric Chromosomes
Ring Chromosomes
Spiral Chromosomes
Chromosome breaks
- Answer
-
Spiral Chromosomes
7. Structural changes in chromosomes include the following EXCEPT:
Aneuploidy
Inversion
Translocation
Deletion
- Answer
-
Aneuploidy
8. Addition or deletion of nucleotides in the DNA sequence results in the change of the entire DNA or amino acid sequence. This process is known as:
Frame shift
Base-pair substitution mutation
Qualitative change in nucleotide
Right shift
- Answer
-
Frame shift
9. In Allele-Specific PCR, fluorescent reporter probes are added to the reaction mixture, one fluorescent reporter probe is selected for the wild type and the other fluorescent probe is used for the mutant.
True
False
- Answer
-
true
10. The analysis of image to determine DNA damage in comet assay is calculated for the ______ and _______.
“tail length” and “head length”
“head length” and “head moment”
“head length” and “tail moment”
“tail length” and “tail moment”
- Answer
-
“tail length” and “tail moment”
11. Cells which stain negative for both fluorescein isothiocyanate Annexin V and propidium iodide in flow cytometric analysis for necrosis assay are:
Dead and undergoing apoptosis and necrosis
Alive and not undergoing apoptosis or necrosis
Dead and undergoing necrosis only
Alive and undergoing apoptosis only
- Answer
-
Alive and not undergoing apoptosis or necrosis
12. Histone Modification Assay uses Chromatin immunoprecipitation assay (ChIP) followed by:
Hybridization to microarrays (ChIP-chip)
Immunofluorescence
Fluorescence spectroscopy
Fluorescence microscope
- Answer
-
Hybridization to microarrays (ChIP-chip)