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Section 3 Final Evaluation

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    309465
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    1. _______ is a method used in analyzing base substitution mutation resulting from single nucleotide polymorphism.

    Micronucleus assay

    Chromosome aberration study

    Allele-Specific PCR

    Chromatography

    Answer

    Allele-Specific PCR

    2. Proteomic assay analyzes the effect of toxicants in cellular toxicity signaling pathways or mechanisms through:

    Immunofluorescence

    Immunoblot

    Immunoprecipitation

    All of the above

    Answer

    All of the above

    3. In Ladder Assay, fragmented DNA can be separated by agarose gel electrophoresis and can be visualized as “ladder” by __________ staining.

    Ethidium bromide

    Eosin

    Gram

    Wright’s

    Answer

    Ethidium bromide

    4. Trisomy is a form of aneuploidy interpreted as:

    Single missing chromosome from diploid set.

    Three copies of a single chromosome from a diploid set

    Three copies of a single chromosome from a triploid set

    Single missing chromosome from a triploid set

    Answer

    Three copies of a single chromosome from a diploid set

    5. Gene mutations in which a single base nucleotide is replaced by another nucleotide are known as:

    Frame shift

    Quantitative change in nucleotide

    Qualitative change in nucleotide

    Left shift

    Answer

    Qualitative change in nucleotide

    6. Some structural chromosomal aberrations caused by genotoxic chemicals in cytogenetic assays of mammalian cells include the following EXCEPT:

    Dicentric Chromosomes

    Ring Chromosomes

    Spiral Chromosomes

    Chromosome breaks

    Answer

    Spiral Chromosomes

    7. Structural changes in chromosomes include the following EXCEPT:

    Aneuploidy

    Inversion

    Translocation

    Deletion

    Answer

    Aneuploidy

    8. Addition or deletion of nucleotides in the DNA sequence results in the change of the entire DNA or amino acid sequence. This process is known as:

    Frame shift

    Base-pair substitution mutation

    Qualitative change in nucleotide

    Right shift

    Answer

    Frame shift

    9. In Allele-Specific PCR, fluorescent reporter probes are added to the reaction mixture, one fluorescent reporter probe is selected for the wild type and the other fluorescent probe is used for the mutant.

    True

    False

    Answer

    true

    10. The analysis of image to determine DNA damage in comet assay is calculated for the ______ and _______.

    “tail length” and “head length”

    “head length” and “head moment”

    “head length” and “tail moment”

    “tail length” and “tail moment”

    Answer

    “tail length” and “tail moment”

    11. Cells which stain negative for both fluorescein isothiocyanate Annexin V and propidium iodide in flow cytometric analysis for necrosis assay are:

    Dead and undergoing apoptosis and necrosis

    Alive and not undergoing apoptosis or necrosis

    Dead and undergoing necrosis only

    Alive and undergoing apoptosis only

    Answer

    Alive and not undergoing apoptosis or necrosis

    12. Histone Modification Assay uses Chromatin immunoprecipitation assay (ChIP) followed by:

    Hybridization to microarrays (ChIP-chip)

    Immunofluorescence

    Fluorescence spectroscopy

    Fluorescence microscope

    Answer

    Hybridization to microarrays (ChIP-chip)


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