Skip to main content
Chemistry LibreTexts

Enkephalines

  • Page ID
    79355
  • \( \newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}} } \) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash {#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)

    Enkephalins (penta-peptides) have recently been discovered as regulators of nerve impulses involving pain in the brain. Apparently these peptides act as natural analgesics (pain-killers) and their action mimics that of morphine and other opiates. At present it is thought that the morphine-like effects are due to aromatic side chains on phenylanine and tyrosine which mimic a similar sturcture on morphine. Apparently, it does not make much difference whether the enkephalin contains methionine or leucine at the acid end of the peptide. The primary structures are:

    methionine-enkephaline: tyr - gly - gly - phe - met
    leucine-enkephalin: tyr - gly - gly - phe - leu

    564glyalaleu.gif

    QUES. Write the peptide structure for methionine-enkephalin. Enkephalin - Met - Chime in new window

    Quiz:Which amino acid is the N-terminal one?
    Which amino acid is the C-terminal one?

    Contributors and Attributions

     


    Enkephalines is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts.

    • Was this article helpful?