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Chemistry LibreTexts

Kolbe Carboxylation

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Preparation of Salicylic acid (1), the precursor to aspirin (2), via carboxylation of phenol (3) is known as Kolbe carboxylation.

kolbecarboxylation1.png

mechanism:

kolbecarboxylation2.png


This page titled Kolbe Carboxylation is shared under a All Rights Reserved (used with permission) license and was authored, remixed, and/or curated by Gamini Gunawardena via source content that was edited to the style and standards of the LibreTexts platform.

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