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Hofmann Degradation

[ "article:topic", "authorname:ggunawardena" ]
  • Page ID
    40455
  • Hofmann rearrangement, also known as Hofmann degradation and not to be confused with Hofmann elimination, is the reaction of a primary amide with a halogen (chlorine or bromine) in strongly basic (sodium or potassium hydroxide) aqueous medium, which converts the amide to a primary amine. eg:

    Mechanism

     

     

    see also nitrene