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Baeyer-Villiger Oxidation

[ "article:topic", "authorname:ggunawardena" ]
  • Page ID
    39001
  • Baeyer-Villiger oxidation is the oxidation of ketones to carboxylic acid esters using a peroxyacid as the oxidizing agent.

     

     

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    Mechanism:

     

     

    When the two ligands on the carbonyl carbon in the ketone are different, Baeyer-Villiger oxidation is regioselective.  Of the two alpha carbons in the ketone, the one that can stabilize a positive charge more effectively, which is the more highly substituted one, migrates from carbon to oxygen preferentially.

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