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Baeyer-Villiger Oxidation

Last updated

Feb 28, 2022
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- Axial Bond
- Base

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Baeyer-Villiger oxidation is the oxidation of ketones to carboxylic acid esters using a peroxyacid as the oxidizing agent.

eg. 1:

eg. 2:

Mechanism:

When the two ligands on the carbonyl carbon in the ketone are different, Baeyer-Villiger oxidation is regioselective. Of the two alpha carbons in the ketone, the one that can stabilize a positive charge more effectively, which is the more highly substituted one, migrates from carbon to oxygen preferentially.

eg. 1:

eg. 2:

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