Skip to main content
Chemistry LibreTexts

Baeyer-Villiger Oxidation

  • Page ID
    39001
  • Baeyer-Villiger oxidation is the oxidation of ketones to carboxylic acid esters using a peroxyacid as the oxidizing agent.

    eg. 1:

    eg. 2:

    Mechanism:

    When the two ligands on the carbonyl carbon in the ketone are different, Baeyer-Villiger oxidation is regioselective. Of the two alpha carbons in the ketone, the one that can stabilize a positive charge more effectively, which is the more highly substituted one, migrates from carbon to oxygen preferentially.

    eg. 1:

    eg. 2: