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Chemistry LibreTexts

Active Methylene Compound

[ "article:topic", "authorname:ggunawardena" ]
  • Page ID
    16564
  • An active methylene compound is a compound that has the following general structural formula.

     

     

    E1, E2 = a functional group that withdraws electrons by resonance

     

    eg:

     

    activemethylenecompound2.png

     

    The conjugate base of an active methylene compound is highly resonance stabilized.

    eg:

     

    activemethylenecompound3.png

     

    Consequently, active methylene compounds are highly acidic and can be deprotonated, for all practical purposes, irreversibly, using common strong bases, such as the hydroxide ion or alkoxide ions.

     

    activemethylenecompound4.png

     

    Notice that the equilibrium constant, K, is very large.

     

    activemethylenecompound5.png