Michael Additions & Robinson Annulation
- Page ID
- 5141
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Enolates undergo 1,4 addition to α, β-unsaturated carbonyl compounds is a process called a Michael addition. The reaction is named after American chemist Arthur Michael (1853-1942).
Examples of Michael Additions
Robinson Annulation
Many times the product of a Michael addition produces a dicarbonyl which can then undergo an intramolecular aldol reaction. These two processes together in one reaction creates two new carbon-carbon bonds and also creates a ring. Ring-forming reactions are called annulations after the Latin work for ring annulus. The reaction is named after English chemist Sir Robert Robinson (1886-1975) who developed it. He received the Nobel prize in chemistry in 1947. Remember that during annulations five and six membered rings are preferred.
Examples of Robinson Annulations
Contributors
Prof. Steven Farmer (Sonoma State University)