Biological Properties of Material
A living organism has a material structure to provide an environment for complicated chemistry of living. Chemical and physical reactions provide energy to maintain living functions and to renew structural material. Thus, consideration of biological properties is a natural extension of physical and chemical properties.
To a large extend, biological functions of any materials are related to their chemical and physical properties. However, reactions in biological systems are catalyzed by enzymes. Furthermore, products of one reaction may be reactants for another in a complicate scheme of reactions to maintain live. Malfunction of a reaction causes trouble, leading to disease or death. Thus, biological properties deserve special consideration.
Absorption and Transport
|Biological memberance as barriers|
|Ions K+, Na+, Cl-, and CO32- must be |
transported across cell membranes in cells.
|Na+, Cl-||Cell membrane encloses a |
special system for chemical
reactions. _ K+, CO32- _
Generally speaking, food, medicine, and toxin can be given to a person by means of feeding, absorption, inhalation and injection. Food must be absorbed in the digestive track and transported from to the targeted organs, tissues and cells to provide energy for life. Injected substances may already be in organs or tissues, but they may not be in the targeted cells. In any cases, materials in question must pass through membranes, either by enzyme aided (active) transport or by diffusion (passive transport). Transportation of a substance in a biological system is a very complicated process.
Absorption and transport of a substance often involve its solubility in the medium. Substances prefer to dissolve in water type fluid are said to be hydrophilic, whereas those prefer to dissolve in oily fluids are lipophilic. Absorption and transport of substances depend on their solubility in water and lipid media. The ultimate effect on cells, tissues, and organs must take place at the molecular level. However, effects at the molecular level are often not observable, and the symptoms of these effects may appear to be unrelated to the material in question.
Solid substances such as fiber, gold and charcoal, not absorbed and used in any biological function pass out as feces. Absorbed soluble substances, but not utilized by animals are excreted with urine.
Material for Biological Structure
Bullets and shell fragments anchored in bones of war veterans were not removed, because doctors considered them biologically inert. Stainless steel parts replace joints and bones today, because they are inert.
Both inorganic and organic materials are involved in structures of living organism. Lignin, cellulose, muscles, skins, and cell walls are mostly organic, whereas bones, teeth, and shells involve mostly inorganic substances. These substances may serve only as structural materials in biological systems, and if so they can be replaced by biological inert substances.
However some subsystems of structural organs are responsible for vital biological functions. For example, bone marrow is responsible for blood regeneration. Thus, replacement of biological structure material involves many disciplines.
Biological Materials and Biomaterial
Plasma, membrane, tissue, protein, lipid, enzyme, the digestive system, and the central nervous systems are some examples of biological materials, for which properties for consideration include growth and decay, turn over time, biological half life, retention time, composition and its change, and active ingredient. These are manifestation of physical and chemical properties of biological materials. However, biological properties allow us to identify and solve the biological problems. Biological materials had been studied by biologists, chemists, and engineers from the macroscopic, molecular, and functional view points.
In contrast, replacement or implant materials that imitate living tissues or organs are called biomaterial, which can be divided into two categories: soft tissue and hard tissue replacement biomaterial. The former includes sutures, surgical tapes, adhesives, skin implants etc. The latter include metals (steel, aluminum, titanium, cobalt-based alloys, and titanium-based alloys); ceramics (made up of Al2O3, TiO2, SiO2, Fe2O3 etc.); carbon (graphite and glassy carbon); and polymers.
The chemistry of living is complex, and properties of biological materials towards biomaterials are of great interest. The general reaction of biological materials towards foreign biomaterials is expel (or rejection). Living tissues form a thin layer around the inert biomaterial, but materials that irritate the tissues causes inflammation. Most pure metals evoke severe tissue reaction due to their redox reactions. However, aluminum and titanium are metals of choice, because the formation of a thin oxide layer on their surface made them inert. Similarly, ceramics are compatible to body fluid because they are made of the metal oxides. The nature of the surface also affects the biological properties, rough ones enable tight attachment of tissues.
Biological activities of materials can be divided according to biological functions. Substances that provide nutrition, energy, and structural need are called food, whereas those that disrupt the normal functions are called toxins. Substances used to correct the abnormal biological functions are called medicines.
In recent years, a lot of research had gone into finding quantitative structure-activity relationships (QSAR) of various substances aimed at improving drug design. As they provide an indication of some biological activity, we list some categories here:
- anti-infective agents,
- anti-tumor agents,
- cardiovascular agents,
- anti-allergic, anti-ulcer,
- anti-inflammatory, and
Agents affecting the central nervous system includes analgesics, anesthetics, antidepressants, convulsants, anti-convulsants, neuroleptics, and psychotomimetics. There are also steroids and hormones which interacts with genes in the nuclei of cells causing complicated developments.
- Describe the following pairs of terms:
- ionic and molecular molecules
- polar and nonpolar molecules
- active and passive transports
- hydrophilic and lipophilic materials
- biological material and biomaterial
- convulsants and anticonvulsants
- What properties of ceramic make it a suitable biomaterial?
- What are biological properties of material? Give some medicicinal functions of drugs.
Chung (Peter) Chieh (Chemistry, University of Waterloo)