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Brompheniramine

  • Page ID
    74864
  • [ "article:topic" ]

    • Main ChemSpider page
    • Molecular formula: C16H19BrN2
    • Molar mass: 319.240
    • CAS Registry Number: Not available
    • Appearance: Not available
    • Melting point: Not available
    • Boiling point: Not available
    • Solubility: Not available
    • Safety sheet: Not available
    • Spectra: Massbank MS (123456789101112), also check on SDBSAdd Spectra (Help).

    From Wikipedia

    Brompheniramine (BromfedDimetappBromfenexDimetaneBPNLodrane), commonly marketed as its salt brompheniramine maleate, is an antihistamine drug of the propylamine (alkylamine) class. It is readily available over the counter and is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. It is a first-generation antihistamine.

    Brompheniramine is part of a series of antihistamines including pheniramine (Naphcon) and its halogenated derivatives and others including fluorpheniraminechlorpheniraminedexchlorpheniramine (Polaramine), triprolidine (Actifed), and iodopheniramine.

    The halogenated alkylamine antihistamines all exhibit optical isomerism and brompheniramine products contain racemic brompheniramine maleate whereas dexbrompheniramine (Drixoral) is the dextrorotary (right-handed) stereoisomer.

    Brompheniramine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin and norepinephrine. Based on this knowledge, Arvid Carlsson and his colleagues, working at the Swedish company Astra AB, were able to derive the first marketed selective serotonin reuptake inhibitorzimelidine, from brompheniramine.

    Like other agents of this type, brompheniramine also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 percent.

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    Other names

    3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (IUPAC Name); gamma-(4-Bromophenyl)-n,n-dimethyl-2-pyridinepropanamine; 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; Parabromodylamine