This page discusses the isolation of urease by James Sumner in 1926, highlighting its role as the first enzyme and earning Sumner a Nobel Prize in 1946. It explains enzymes as biological catalysts tha...This page discusses the isolation of urease by James Sumner in 1926, highlighting its role as the first enzyme and earning Sumner a Nobel Prize in 1946. It explains enzymes as biological catalysts that facilitate reactions by binding substrates at active sites, and describes how inhibitors can disrupt their function either competitively or non-competitively. Additionally, it notes that some enzymes need cofactors, which are non-protein molecules essential for their activity.