In the absence of pKa values, the relative strength of an organic acid can be predicted based on the stability of the conjugate base that it forms. The acid that forms the more stable conjugate base ...In the absence of pKa values, the relative strength of an organic acid can be predicted based on the stability of the conjugate base that it forms. The acid that forms the more stable conjugate base will be the stronger acid. The common factors that affect the conjugate base's stability are 1) the size and electronegativity of the the atom that has lost the proton, 2) resonance effects, 3) inductive effects, and 4) solvation effects.
