Or do you think about the fact that the skin belongs to one of the body’s most essential and dynamic systems: the integumentary system? In the adult human body, the skin makes up about 16 percent of b...Or do you think about the fact that the skin belongs to one of the body’s most essential and dynamic systems: the integumentary system? In the adult human body, the skin makes up about 16 percent of body weight and covers an area of 1.5 to 2 m 2 . In fact, the skin and accessory structures are the largest organ system in the human body.