Alpha-substitution reactions are the third major type of reaction that you will study in your investigation of the chemistry of carbonyl compounds. As you will see, these reactions proceed through the...Alpha-substitution reactions are the third major type of reaction that you will study in your investigation of the chemistry of carbonyl compounds. As you will see, these reactions proceed through the formation of the enol form of the carbonyl compound. After a brief review of keto-enol tautomerism, we begin our discussion of alpha-substitution reactions by looking at the methods used to introduce a halogen atom into a carbonyl-containing compound—reactions.