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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_II_(Morsch_et_al.)/23%3A_Carbonyl_Condensation_Reactions/23.05%3A_Mixed_Aldol_Reactionsidentify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. 2) One of the...identify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. 2) One of the reactants has alpha-hydrogens which are highly acidic: The acidic compound will be preferably converted into an enolate donor which removes the possibility of its carbonyl acting as an electrophilic acceptor.
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/23%3A_Carbonyl_Condensation_Reactions/23.06%3A_Mixed_Aldol_ReactionsIf one of the carbonyl partners contains no α hydrogens (and thus can’t form an enolate ion to become a donor), but does contain an unhindered carbonyl group (and so is a good acceptor of nucleophiles...If one of the carbonyl partners contains no α hydrogens (and thus can’t form an enolate ion to become a donor), but does contain an unhindered carbonyl group (and so is a good acceptor of nucleophiles), then a mixed aldol reaction is likely to be successful.
- https://chem.libretexts.org/Courses/Smith_College/CHM_223_Chemistry_III%3A_Organic_Chemistry_(2024)/07%3A_Carbonyl_Condensation_Reactions/7.06%3A_Mixed_Aldol_Reactionsidentify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. 2) One of the...identify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. 2) One of the reactants has alpha-hydrogens which are highly acidic: The acidic compound will be preferably converted into an enolate donor which removes the possibility of its carbonyl acting as an electrophilic acceptor.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/23%3A_Carbonyl_Condensation_Reactions/23.05%3A_Mixed_Aldol_ReactionsThe page on mixed aldol reactions explores how these reactions involve two different aldehydes or ketones, leading to cross-condensation products. Mixed aldol reactions can create a variety of product...The page on mixed aldol reactions explores how these reactions involve two different aldehydes or ketones, leading to cross-condensation products. Mixed aldol reactions can create a variety of products, and selectivity is crucial to obtain the desired product. Reaction conditions, including the choice of base and solvent, can influence product formation. This strategy is used in organic synthesis to construct more complex molecules from simpler starting materials.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/23%3A_Carbonyl_Condensation_Reactions/23.06%3A_Mixed_Aldol_Reactionsidentify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. 2) One of the...identify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. 2) One of the reactants has alpha-hydrogens which are highly acidic: The acidic compound will be preferably converted into an enolate donor which removes the possibility of its carbonyl acting as an electrophilic acceptor.
- https://chem.libretexts.org/Courses/University_of_Alberta_Augustana_Campus/AUCHE_252_-_Organic_Chemistry_II/05%3A_Aldehydes_and_Ketones/5.09%3A_Mixed_Aldol_ReactionsThe previous examples of aldol reactions and condensations used a common reactant as both the enolate donor and the electrophilic acceptor. This makes the preferred reaction one with the ketone as an ...The previous examples of aldol reactions and condensations used a common reactant as both the enolate donor and the electrophilic acceptor. This makes the preferred reaction one with the ketone as an enoloate donor and the aldehyde as an electrophilic acceptor. 2) One of the reactants has alpha-hydrogens which are highly acidic: The acidic compound will be preferably converted into an enolate donor which removes the possibility of its carbonyl acting as an electrophilic acceptor.
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/09%3A_Carbonyl_Condensation_Reactions/9.06%3A_Mixed_Aldol_Reactionsidentify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. One of the re...identify the structural features necessary to ensure that two carbonyl compounds will react together in a mixed aldol reaction to give a single product rather than a mixture of products. One of the reactants has alpha-hydrogens which are highly acidic: The acidic compound will be preferably converted into an enolate donor which removes the possibility of its carbonyl acting as an electrophilic acceptor.
