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  • https://chem.libretexts.org/Courses/Williams_School/Advanced_Chemistry/15%3A_Neurochemistry/15.04%3A_No_Pain_Your_Gain
    The bark of the willow tree contains a substance called salicin, a known antidote to headache and fever since the time of the Greek physician Hippocrates, around 400 B.C. Bayer® scientist Felix Hoffma...The bark of the willow tree contains a substance called salicin, a known antidote to headache and fever since the time of the Greek physician Hippocrates, around 400 B.C. Bayer® scientist Felix Hoffman discovered that adding a chemical tag called an acetyl group (see figure, page 20) to salicylate made the molecule less acidic and a little gentler on the stomach, but the chemical change did not seem to lessen the drug's ability to relieve his father's rheumatism.
  • https://chem.libretexts.org/Workbench/Pick_Your_Poison%3A_Introduction_to_Materials_Toxicology/33%3A_Body_Heal_Thyself/33.03%3A_No_Pain_Your_Gain
    The bark of the willow tree contains a substance called salicin, a known antidote to headache and fever since the time of the Greek physician Hippocrates, around 400 B.C. Bayer® scientist Felix Hoffma...The bark of the willow tree contains a substance called salicin, a known antidote to headache and fever since the time of the Greek physician Hippocrates, around 400 B.C. Bayer® scientist Felix Hoffman discovered that adding a chemical tag called an acetyl group (see figure, page 20) to salicylate made the molecule less acidic and a little gentler on the stomach, but the chemical change did not seem to lessen the drug's ability to relieve his father's rheumatism.

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