The earliest examples of metal–ligand complexation titrations are Liebig’s determinations, in the 1850s, of cyanide and chloride using, respectively, \(\text{Ag}^+\) and \(\text{Hg}^{2+}\) as the titr...The earliest examples of metal–ligand complexation titrations are Liebig’s determinations, in the 1850s, of cyanide and chloride using, respectively, \(\text{Ag}^+\) and \(\text{Hg}^{2+}\) as the titrant. Practical applications were slow to develop because many metals and ligands form a series of metal–ligand complexes. In 1945, Schwarzenbach introduced EDTA as a titrant. The availability of a ligand that gives a single endpoint made complexation titrimetry a practical analytical method.
The earliest examples of metal–ligand complexation titrations are Liebig’s determinations, in the 1850s, of cyanide and chloride using, respectively, \(\text{Ag}^+\) and \(\text{Hg}^{2+}\) as the titr...The earliest examples of metal–ligand complexation titrations are Liebig’s determinations, in the 1850s, of cyanide and chloride using, respectively, \(\text{Ag}^+\) and \(\text{Hg}^{2+}\) as the titrant. Practical applications were slow to develop because many metals and ligands form a series of metal–ligand complexes. In 1945, Schwarzenbach introduced EDTA as a titrant. The availability of a ligand that gives a single endpoint made complexation titrimetry a practical analytical method.
