As we noted earlier, several variables must be considered, the most important being the structure of the alkyl group and the nature of the nucleophilic reactant.In general, in order for an SN1 or E1 r...As we noted earlier, several variables must be considered, the most important being the structure of the alkyl group and the nature of the nucleophilic reactant.In general, in order for an SN1 or E1 reaction to occur, the relevant carbocation intermediate must be relatively stable. S N 2 substitution. (N ≈ S >>O) In high dielectric ionizing solvents, such as water, dimethyl sulfoxide & acetonitrile, S N 1 and E1 products may be formed slowly.
