The following equations and formulas illustrate how the presence of two or more substituents on a cyclohexane ring perturbs the interconversion of the two chair conformers in ways that can be predicte...The following equations and formulas illustrate how the presence of two or more substituents on a cyclohexane ring perturbs the interconversion of the two chair conformers in ways that can be predicted. In 1-t-butyl-1-methylcyclohexane the t-butyl group is much larger than the methyl, and that chair conformer in which the larger group is equatorial will be favored in the equilibrium( > 99%).
