Yet another cyclic pathway important in cells is the urea cycle (Figure 7.5.1). With reactions spanning the cytoplasm and the mitochondria, the urea cycle occurs mostly in the liver and kidney. The cy...Yet another cyclic pathway important in cells is the urea cycle (Figure 7.5.1). With reactions spanning the cytoplasm and the mitochondria, the urea cycle occurs mostly in the liver and kidney. The cycle plays an important role in nitrogen balance in cells and is found in organisms that produce urea as a way to excrete excess amines.