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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/00%3A_Front_Matter/04%3A_LicensingA detailed breakdown of this resource's licensing can be found in Back Matter/Detailed Licensing.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/zz%3A_Back_Matter
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/02%3A_Rules_and_Guidelines_Governing_Organic_Synthesis/2.03%3A_Cram's_Rule_and_Prelog's_RuleCram defined a Reactive conformation, as the least energy conformation in which the chemical reaction takes place. An extension of Cram's idea of reactive conformation to chiral esters of α -ketoeste...Cram defined a Reactive conformation, as the least energy conformation in which the chemical reaction takes place. An extension of Cram's idea of reactive conformation to chiral esters of α -ketoesters(pyruvates) is the Prelog's Rule reported in 19533. It generally relates to Grignard addition to chiral pyruvates made using chiral alcohols .
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/09%3A_Strategies_in_Reserpine_SynthesisThe structure of Reserpine was solved by 1953. R.B. Woodward’s group reported the first synthesis of Reserpine in 1956 (J. Am. Chem. Soc., 78, 2023, 2657 (1956); Tetrahedron, 2, 1 (1958)). His scholar...The structure of Reserpine was solved by 1953. R.B. Woodward’s group reported the first synthesis of Reserpine in 1956 (J. Am. Chem. Soc., 78, 2023, 2657 (1956); Tetrahedron, 2, 1 (1958)). His scholarly analysis clearly displayed aspects of retroanalysis, which was just evolving at that time. This synthesis commands admiration for the way he used conformational analysis and stereoelectronic effects to precisely develop the stereopoints in this exceedingly complex problem for that time.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/13%3A_Synthesis_of_Vitamin_BThe total synthesis of Vitamin B₁₂ was accomplished in 1973 by a grand collaboration between R. B. Woodward’s group at Harvard University (USA) and A. Eschenmoser’s group, Swiss Federal Institute of T...The total synthesis of Vitamin B₁₂ was accomplished in 1973 by a grand collaboration between R. B. Woodward’s group at Harvard University (USA) and A. Eschenmoser’s group, Swiss Federal Institute of Technology (ETH), Zürich, Switzerland. It took about twelve years and more than two dozen senior scientists to complete this gigantic task. The achievement is variously eulogized by organic chemists – monumental achievement in the annals of organic synthetic chemists.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/zz%3A_Back_Matter/20%3A_GlossaryExample and Directions Words (or words that have the same definition) The definition is case sensitive (Optional) Image to display with the definition [Not displayed in Glossary, only in pop-up on pag...Example and Directions Words (or words that have the same definition) The definition is case sensitive (Optional) Image to display with the definition [Not displayed in Glossary, only in pop-up on pages] (Optional) Caption for Image (Optional) External or Internal Link (Optional) Source for Definition "Genetic, Hereditary, DNA ...") (Eg. "Relating to genes or heredity") The infamous double helix CC-BY-SA; Delmar Larsen Glossary Entries Definition Image Sample Word 1 Sample Definition 1
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/02%3A_Rules_and_Guidelines_Governing_Organic_SynthesisThere are a few rules that provide guidelines for planning strategies in organic synthesis. These rules and guidelines have come from the keen observations of chemists after looking into several examp...There are a few rules that provide guidelines for planning strategies in organic synthesis. These rules and guidelines have come from the keen observations of chemists after looking into several examples from their own research and other published work in the literature. These observations are to be treated as thumb-rules to be applied with caution. They may not be applicable for all situations. Nonetheless, they serve as guidelines to avoid pit-falls in planning.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/00%3A_Front_Matter/02%3A_InfoPageThe LibreTexts libraries are Powered by NICE CXOne and are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the Californi...The LibreTexts libraries are Powered by NICE CXOne and are supported by the Department of Education Open Textbook Pilot Project, the UC Davis Office of the Provost, the UC Davis Library, the California State University Affordable Learning Solutions Program, and Merlot.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/zz%3A_Back_Matter/30%3A_Detailed_Licensing
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/00%3A_Front_Matter
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/06%3A_Strategies_in_(-)-Menthol_Synthesis(-)-Menthol is amongst the most important perfume / flavor chemical, extensively used in pharmaceuticals, cosmetics, toothpastes, chewing gums and toiletries. Out a the estimated total production of a...(-)-Menthol is amongst the most important perfume / flavor chemical, extensively used in pharmaceuticals, cosmetics, toothpastes, chewing gums and toiletries. Out a the estimated total production of about 20,000 m.tons, natural menthol accounts to about 13 m.tons, the rest coming from synthetic sources. The natural source - oil of Mentha Arvensis - being erratic due to dependence on monsoon, the demand for synthetic menthol is on the increase.
