The pyruvate dehydrogenase complex links glycolysis to the TCA cycle (also known as the Krebs cycle or the citric acid cycle). It is a large multi-enzyme complex composed of three enzymes involving f...The pyruvate dehydrogenase complex links glycolysis to the TCA cycle (also known as the Krebs cycle or the citric acid cycle). It is a large multi-enzyme complex composed of three enzymes involving five cofactors. The pyruvate dehydrogenase complex oxidizes pyruvate to generate acetyl-coA.