Bioconjugation is a chemical technique used to couple two molecules together, at least one of which is a biomolecule, such as a carbohydrate, nucleic acid, or protein. Proteins are especially diverse ...Bioconjugation is a chemical technique used to couple two molecules together, at least one of which is a biomolecule, such as a carbohydrate, nucleic acid, or protein. Proteins are especially diverse biomolecules due to the variety of amino acids available and are thus important substrates in bioconjugation reactions. Bioconjugation reactions play a critical role in the modification of proteins.