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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(Morsch_et_al.)/22%3A_Carbonyl_Alpha-Substitution_Reactions/22.00%3A_Chapter_Objectives_and_Introduction_to_Carbonyl_Alpha-Substitution_ReactionsAn “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These ...An “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of a hydrogen attached to an α-carbon with some type of electrophile.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/22%3A_Carbonyl_Alpha-Substitution_Reactions/22.00%3A_Why_This_ChapterWe said in the Preview of Carbonyl Chemistry that much of the chemistry of carbonyl compounds can be explained by just four fundamental reaction types: nucleophilic additions, nucleophilic acyl substi...We said in the Preview of Carbonyl Chemistry that much of the chemistry of carbonyl compounds can be explained by just four fundamental reaction types: nucleophilic additions, nucleophilic acyl substitutions, α substitutions, and carbonyl condensations. Alpha-substitution reactions occur at the position next to the carbonyl group—the α position—and involve the substitution of an α hydrogen atom by an electrophile, E, through either an enol or enolate ion intermediate.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/22%3A_Carbonyl_Alpha-Substitution_Reactions/22.01%3A_Chapter_Objectives_and_Introduction_to_Carbonyl_Alpha-Substitution_ReactionsAn “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These ...An “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of a hydrogen attached to an α-carbon with some type of electrophile.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_II_(Morsch_et_al.)/22%3A_Carbonyl_Alpha-Substitution_Reactions/22.00%3A_Chapter_Objectives_and_Introduction_to_Carbonyl_Alpha-Substitution_ReactionsAn “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These ...An “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of a hydrogen attached to an α-carbon with some type of electrophile.
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/22%3A_Carbonyl_Alpha-Substitution_Reactions/22.01%3A_Why_This_ChapterWe said in the Preview of Carbonyl Chemistry that much of the chemistry of carbonyl compounds can be explained by just four fundamental reaction types: nucleophilic additions, nucleophilic acyl substi...We said in the Preview of Carbonyl Chemistry that much of the chemistry of carbonyl compounds can be explained by just four fundamental reaction types: nucleophilic additions, nucleophilic acyl substitutions, α substitutions, and carbonyl condensations. Alpha-substitution reactions occur at the position next to the carbonyl group—the α position—and involve the substitution of an α hydrogen atom by an electrophile, E, through either an enol or enolate ion intermediate.
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/08%3A_Carbonyl_Alpha-Substitution_Reactions/8.01%3A_Chapter_Objectives_and_Introduction_to_Carbonyl_Alpha-Substitution_ReactionsAn “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These ...An “alpha‑substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of a hydrogen attached to an α-carbon with some type of electrophile.
- https://chem.libretexts.org/Courses/Smith_College/CHM_223_Chemistry_III%3A_Organic_Chemistry_(2024)/06%3A_Carbonyl_Alpha-Substitution_Reactions/6.01%3A_Chapter_Objectives_and_Introduction_to_Carbonyl_Alpha-Substitution_ReactionsAn “alpha substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These ...An “alpha substitution reaction” of a carbonyl compound is a reaction in which one of the hydrogen atoms on the carbon adjacent to the carbonyl group is substituted by some other atom or group. These reactions, which can be regarded as the backbone of much synthetic organic chemistry, usually result in the replacement of a hydrogen attached to an α-carbon with some type of electrophile.
