An acid is a substance whose molecules donate positive hydrogen ions (protons) to other molecules or ions. When dissolved in pure water, acid molecules will transfer a hydrogen ion to a water molecule...An acid is a substance whose molecules donate positive hydrogen ions (protons) to other molecules or ions. When dissolved in pure water, acid molecules will transfer a hydrogen ion to a water molecule or to a cluster of several water molecules. A base is a substance whose molecules accept hydrogen ions from other molecules.