The Schmidt reaction is the reaction of hydrazoic acid or an alkyl azide with a carbonyl compound, alkene, or alcohol, often in the presence of a Brønsted or Lewis acid. Although the family of Schmidt...The Schmidt reaction is the reaction of hydrazoic acid or an alkyl azide with a carbonyl compound, alkene, or alcohol, often in the presence of a Brønsted or Lewis acid. Although the family of Schmidt reactions includes a number of variants, they all result in the migration of a substituent from carbon to nitrogen with loss of a molecule of dinitrogen. This reaction has considerable utility for the synthesis of hindered or cyclic amides and amines.
