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- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Map%3A_Organic_Chemistry_(Smith)/21%3A_Substitution_Reactions_of_Carbonyl_Compounds_at_the_Alpha_Carbon/21.10%3A_Malonic_Ester_SynthesisMalonic ester is a reagent specifically used in a reaction which converts alkyl halides to carboxylic acids called the Malonic Ester Synthesis. Malonic ester synthesis is a synthetic procedure used to...Malonic ester is a reagent specifically used in a reaction which converts alkyl halides to carboxylic acids called the Malonic Ester Synthesis. Malonic ester synthesis is a synthetic procedure used to convert a compound that has the general structural formula 1 into a carboxylic acid that has the general structural formula 2. A more direct method to convert 3 into 4 is the reaction of 3 with the enolate ion (5) of ethyl acetate followed by hydrolysis of the resultant ester.
- https://chem.libretexts.org/Ancillary_Materials/Reference/Organic_Chemistry_Glossary/Malonic_Ester_SynthesisMalonic ester synthesis is a synthetic procedure used to convert a compound that has the general structural formula 1 into a carboxylic acid that has the general structural formula 2. The group —CH 2 ...Malonic ester synthesis is a synthetic procedure used to convert a compound that has the general structural formula 1 into a carboxylic acid that has the general structural formula 2. The group —CH 2 CO 2 H in 2 is contributed by a malonic ester, hence the term malonic ester synthesis. A more direct method to convert 3 into 4 is the reaction of 3 with the enolate ion (5) of ethyl acetate followed by hydrolysis of the resultant ester.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/22%3A_Carbonyl_Alpha-Substitution_Reactions/22.07%3A_Alkylation_of_Enolate_IonsThe section on alkylation of enolate ions explains how enolates can react with alkyl halides to form carbon-carbon bonds through nucleophilic substitution. This process typically involves treating the...The section on alkylation of enolate ions explains how enolates can react with alkyl halides to form carbon-carbon bonds through nucleophilic substitution. This process typically involves treating the enolate with a suitable electrophile, leading to the formation of alkylated products. The choice of electrophile and conditions influences the reaction's efficiency and outcome, making alkylation a valuable method in organic synthesis.
