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- https://chem.libretexts.org/Courses/University_of_Connecticut/Chem_2444%3A_(Second_Semester_Organic_Chemistry)_UConn/06%3A_Aryl_Halides_and_Nucleophilic_Aromatic_Substitution_Reactions/6.04%3A_BenzyneThe rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base th...The rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base that produces the benzyne in the elimination step is derived from the nucleophile that adds in the addition step.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_II_(Morsch_et_al.)/16%3A_Chemistry_of_Benzene_-_Electrophilic_Aromatic_Substitution/16.08%3A_BenzyneThe rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base th...The rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base that produces the benzyne in the elimination step is derived from the nucleophile that adds in the addition step.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(OpenStax)/16%3A_Chemistry_of_Benzene_-_Electrophilic_Aromatic_Substitution/16.11%3A_Chemistry_MattersCombinatorial_ChemistryCombinatorial chemistry involves creating diverse libraries of compounds through systematic combinations of chemical building blocks. This approach accelerates drug discovery and materials development...Combinatorial chemistry involves creating diverse libraries of compounds through systematic combinations of chemical building blocks. This approach accelerates drug discovery and materials development by enabling rapid synthesis and evaluation of numerous compounds simultaneously. Techniques like solid-phase synthesis and high-throughput screening are commonly employed to identify promising candidates efficiently.
- https://chem.libretexts.org/Courses/Winona_State_University/Klein_and_Straumanis_Guided/19%3A_Aromatic_Substitution_Reactions/19.10%3A_BenzyneThe rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base th...The rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base that produces the benzyne in the elimination step is derived from the nucleophile that adds in the addition step.
- https://chem.libretexts.org/Courses/Smith_College/CHM_223_Chemistry_III%3A_Organic_Chemistry_(2024)/11%3A_Chemistry_of_Benzene_-_Electrophilic_Aromatic_Substitution/11.09%3A_BenzyneThe rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base th...The rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base that produces the benzyne in the elimination step is derived from the nucleophile that adds in the addition step.
- https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Organic_Chemistry_(Morsch_et_al.)/16%3A_Chemistry_of_Benzene_-_Electrophilic_Aromatic_Substitution/16.08%3A_BenzyneThe elimination-addition mechanism of nucleophilic aromatic substitution involves the remarkable intermediate called benzyne or arynes.
- https://chem.libretexts.org/Workbench/LCDS_Organic_Chemistry_OER_Textbook_-_Todd_Trout/16%3A_Chemistry_of_Benzene_-_Electrophilic_Aromatic_Substitution/16.12%3A_Chemistry_MattersCombinatorial_ChemistryA different building block is added to each group of beads, the different groups are combined, and the reassembled mix is again split to form new groups. Several approaches to this problem have been d...A different building block is added to each group of beads, the different groups are combined, and the reassembled mix is again split to form new groups. Several approaches to this problem have been developed, all of which involve the attachment of encoding labels to each polymer bead to keep track of the chemistry each has undergone.
- https://chem.libretexts.org/Courses/Smith_College/Organic_Chemistry_(LibreTexts)/16%3A_Chemistry_of_Benzene_-_Electrophilic_Aromatic_Substitution/16.09%3A_BenzyneThe rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base th...The rearrangements in these reactions result from the attack of the nucleophile at one or the other of the carbons of the extra bond in the intermediate. In the foregoing benzyne reactions the base that produces the benzyne in the elimination step is derived from the nucleophile that adds in the addition step.
- https://chem.libretexts.org/Courses/can/CHEM_232_-_Organic_Chemistry_II_(Puenzo)/03%3A_Chemistry_of_Benzene_-_Reactions_of_Aromatic_Compounds/3.09%3A_BenzyneThe elimination-addition mechanism of nucleophilic aromatic substitution involves the remarkable intermediate called benzyne or arynes.
