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McLafferty Rearrangement

The McLafferty rearrangement is a characteristic fragmentation of the molecular ion of a carbonyl compound containing at least one gamma hydrogen (see alpha hydrogen), e.g.:



  1. F. W. McLafferty (1959). "Mass Spectrometric Analysis. Molecular Rearrangements". Anal. Chem. 31 (1): 82–87.doi:10.1021/ac60145a015.
  2. Gross ML (2004). "Focus in honor of Fred McLafferty, 2003 Distinguished Contribution awardee, for the discovery of the "McLafferty Rearrangement"". J. Am. Soc. Mass Spectrom.15 (7): 951–5. doi:10.1016/j.jasms.2004.05.009.PMID 15234352.
  3. Nibbering NM (2004). "The McLafferty rearrangement: a personal recollection". J. Am. Soc. Mass Spectrom15 (7): 956-8. doi:10.1016/j.jasms.2004.04.025.PMID 15234353.