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Benzyne Mechanism

Last updated

Feb 28, 2022
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- Benzyne
- Beta Amino Acid

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Two mechanisms have been proposed for nucleophilic aromatic substitution, one of which involves a benzyne as the intermediate and, therefore, is called benzyne mechanism.

eg:

mechanism:

Step 1:

Step 2:

Step 3:

Step 1 requires a very strong base. Thus, for the benzyne mechanism to be operant, the medium must be very strongly basic.

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