Skip to main content
Chemistry LibreTexts

Roadmap Problems in Natural Product synthesis

  • Page ID
    4333
  • [ "article:topic", "authorname:cschaller", "showtoc:no" ]

    Topics required for successful completion are listed under each link.

    Abbysomicin, Sorensen, 2006

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition, Pericyclics

    Annamoxic Acid, Corey, 2004

    Carbonyl addition, Elimination, Alkene addition, Pericyclics

    Anominine, Nicolaou, 2012

    Carbonyl Addition, Aldol, Carboxyl Substitution, Oxidation, Nucleophilic Substitution, Elimination, Radicals

    Aplykurodinone, Danishefsky, 2010

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

    Aza-epothilone B, Danishefsky, 2000

    Carbonyl addition, Carboxylic substitution, Nucleophilic Substitution, Bioassay study

    Callipeltoside, MacMillan, 2008

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition

    Dendrobine, Carreira, 2012

    Carbonyl addition, Carboxylic substitution

    Dynemicin, Danishefsky, 1996

    Carbonyl addition, Carboxylic substitution, Nucleophilic substitution & elimination, Oxidation, Alkene oxidation, Pericyclics

    Echinopine, Nicolaou, 2010

    Carbonyl addition, Carboxylic substitution, Nucleophilic Substitution

    Fischerindole, Baran, 2008

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition, Radicals

    Ginkgolide, Corey, 1988

    Carbonyl addition, Conjugate addition, Enolates, Carboxylic substitution, Nucleophilic substitution, Alkene addition, Rearrangements, Radicals

    Glucosylceramide, Overkleeft, 2007

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

    Contains a bioassay exercise.

    Histrionicotoxin, Corey, 1975

    Carbonyl addition, Carboxylic substitution, Aldol & Claisen, A-lpha-alkylation, Conjugate addition, Oxidation, Nucleophilic Substitution & Elimination

    Juvenile Hormone 1, Corey, 1968

    Carbonyl addition, Phosphorus ylides, Carboxylic substitution, Oxidation, Nucleophilic substitution, Cuprate addition, Alkene addition

    Longifolene, Corey, 1961

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Alkene oxidation

    Nakadomarin, Kerr, 2007

    Carbonyl addition, Conjugate addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

    Okilactomycin, Smith, 2007

    Carbonyl addition, Aldols, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination,  Pericyclics

    Perhydrohistrionicotoxin, Corey, 1975

    Carbonyl addition, Enolates, Conjugate addition, Carboxylic substitution, Oxidation, Nucleophilic substitution & elimination, Radicals

    Periplanone, Still, 1979

    Carbonyl addition, Aldols, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination,  Pericyclics

    Prostaglandin A2, Corey, 1972

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

    Quinine, Stork, 2001

    Carbonyl addition, Carboxylic substitution, Nucleophilic Substitution

    Quinocarcin, Stoltz, 2008

    Carbonyl addition, Carboxylic substitution

    Salvileucalin, Reisman, 2011

    Carbonyl addition, Carboxylic substitution

    Saxitoxin, Du Bois, 2006

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution, Alkene addition

    Contains a bioassay exercise.

    Serotobenine, Fukuyama & Kan, 2008

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Alkene oxidation, Pericyclics

    Solamine, Stark, 2006

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Alkene oxidation

    Strychnine, Overman, 1993

    Carbonyl addition, Enolates, Conjugate addition, Carboxylic substitution, Nucleophilic substitution & elimination, Alkene oxidation

    Exercise: catalytic cycles in transition metal organometallics.

    Taxol, Nicolaou, 1994

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution & elimination, Alkene oxidation, Pericyclics, Radicals

    Tubingensin, Li, 2012

    Carbonyl addition, Carboxylic substitution, Aldol

    Tetrodotoxin, Kishi, 1972

    Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition, Alkene oxidation, Pericyclics, Rearrangements

    Zaragozic acid, Nicolaou, 1994

    Carbonyl addition, Carboxylic Substitution, Sulfur ylides, Oxidation, Nucleophilic substitution, Alkene oxidation, Radicals, Organo-transition metal reactions

    Zincophorin, Hsung, 2007

    Nucleophilic Substitution, Alkene addition