Skip to main content
Chemistry LibreTexts

Conversion of a Carboxylic Acid to an Amide

  • Page ID
    5533
  • The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 oC water is driven off and an amide is formed. 

    General Reaction

    1.jpg

    Going from reactants to products simply

    2.jpg

    Contributors

    Prof. Steven Farmer (Sonoma State University)