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Chemistry LibreTexts

Conversion of Amides into Amines with LiAlH4

  • Page ID
    5891
  • Introduction

    Amides can be converted to 1°, 2° or 3° amines using LiAlH4.

    General Reaction

     

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    Example 1: Amide Reductions

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    Alkyl groups attached to the nitrogen do not affect the reaction.

     

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    Mechanism

     

    1) Nucleophilic attach by the hydride

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    2) Leaving group removal

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    3) Nucleophilic attach by the hydride

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    Contributors

    Prof. Steven Farmer (Sonoma State University)