Amides can be converted to 1°, 2° or 3° amines using LiAlH4.
|Example 1: Amide Reductions|
Alkyl groups attached to the nitrogen do not affect the reaction.
1) Nucleophilic attach by the hydride
2) Leaving group removal
3) Nucleophilic attach by the hydride
Prof. Steven Farmer (Sonoma State University)