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Reactions of Acyl Chlorides with Primary Amines

  • Page ID
    3798
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    This page gives you the facts and a simple, uncluttered mechanism for the nucleophilic addition / elimination reaction between acyl chlorides (acid chlorides) and amines.

    • Ethanoyl chloride is taken as a typical acyl chloride. Any other acyl chloride will behave in the same way. Simply replace the CH3 group in what follows by anything else you want.
    • Similarly, ethylamine is taken as a typical amine. Any other amine will behave in the same way. Replacing the CH3CH2 group by any other hydrocarbon group won't affect the mechanism in any way.

    The reaction between ethanoyl chloride and ethylamine

    Ethanoyl chloride reacts violently with a cold concentrated solution of ethylamine. A white solid product is formed which is a mixture of N-ethylethanamide (an N-substituted amide) and ethylammonium chloride.

    OrganicCore_AcidHalides46.png

    Notice that, unlike the reactions between ethanoyl chloride and water or ethanol, hydrogen chloride isn't produced - at least, not in any quantity. Any hydrogen chloride formed would immediately react with excess ethylamine to give ethylammonium chloride.

    \[CH_3CH_2NH_2 + HCl \rightarrow CH_3CH_2NH_3Cl\]

    The mechanism

    The first stage (the addition stage of the reaction) involves a nucleophilic attack on the fairly positive carbon atom by the lone pair on the nitrogen atom in the ethylamine.

    OrganicCore_AcidHalides47.png

    The second stage (the elimination stage) happens in two steps. In the first, the carbon-oxygen double bond reforms and a chloride ion is pushed off.

    OrganicCore_AcidHalides48.png

    That is followed by removal of a hydrogen ion from the nitrogen. This might happen in one of two ways:

    It might be removed by a chloride ion, producing HCl (which would immediately react with excess ethylamine to give ethylammonium chloride as above) . . .

    OrganicCore_AcidHalides49.png

    and

    \[ CH_3CH_2NH_2 + HCl \rightrrow CH_3CH_2NH_3Cl\]

    . . . or it might be removed directly by an ethylamine molecule.

    OrganicCore_AcidHalides50.png

    The ethylammonium ion, together with the chloride ion already there, makes up the ethylammonium chloride formed in the reaction.

    Contributors

    Jim Clark (Chemguide.co.uk)


    This page titled Reactions of Acyl Chlorides with Primary Amines is shared under a CC BY-NC 4.0 license and was authored, remixed, and/or curated by Jim Clark.

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