19.10: Carboxylic Acid Derivatives: Amides
- Page ID
- 32529
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The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 oC water is driven off and an amide is formed.
General Reaction
Going from reactants to products simply
Contributors
Prof. Steven Farmer (Sonoma State University)