20.13 Reaction of Organometallic Reagents with Carboxylic Acid Derivatives
- Page ID
- 32964
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Addition of Grignard reagents convert esters to 3o alcohols.
In effect the Grignard reagent adds twice.
General Reaction
Example 1: |
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Mechanism
1) Nucleophilic attack
2) Leaving group removal
3) Nucleophilic attack
4) Protonation
Organocuprate reagents convert acid chlorides to ketones
General Reaction
Example 1: |
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Contributors
Prof. Steven Farmer (Sonoma State University)