5: Aldehydes and Ketones- Nucleophilic Addition Reactions
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- 5.7: Nucleophilic Addition via Organometallic Reactions - Alcohol Formation
- This section explains the nucleophilic addition reactions of aldehydes and ketones using hydride and Grignard reagents to form alcohols. Hydride reagents like sodium borohydride and lithium aluminum hydride reduce carbonyl compounds, while Grignard reagents, being strong nucleophiles, add to carbonyls to yield alcohols after hydrolysis. The text emphasizes the mechanisms, products, and implications of these reactions in organic synthesis.
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- 5.12: Nucleophilic Addition of Amines - Imine and Enamine Formation
- The nucleophilic addition of amines involves reacting primary or secondary amines with carbonyl compounds like aldehydes or ketones. This forms imines (with primary amines) or enamines (with secondary amines) along with water as a byproduct. These reactions are crucial in organic synthesis for building carbon-nitrogen bonds and creating various functional groups.