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Asymmetric Alkylation of Enolates

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    13732
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    Morales, M.R.; Mellem, K.T.; Myers, A.G. Angew. Chem. Int. Ed., 2012, 51, 4568–4571.

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    Preparation of Pseudoephedrine and Pseudoephenamine Amides

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    Alkylation of Pseudoephenamine and Pseudoephedrine Amides

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    Diastereoselective Alkylation Reactions

    Hydrolysis of Alkylation Products

    Morales, M.R.; Mellem, K.T.; Myers, A.G. Angew. Chem. Int. Ed., 2012, 51, 4568–4571.

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    Reduction of Alkylation Products

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    Construction of Quaternary Centers

    Enolization–Alkylation

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    Conjugate Addition-Aklyation

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    Transformations of \(\alpha\)-quaternary pseudoephenamine and pseudoephedrine amides

    Hydrolysis of \(\alpha\)-quaternary alkylation products

    Kummer, D. A.; Chain, W. J.; Morales, M. R.; Quiroga, O.; Myers, A. G. J. Am. Chem. Soc. 2008, 130, 13231–13233.

    Addition of alkyllithium reagents to form ketones

    Reduction to form Aldehydes

    LAB reduction to form primary alcohols

    Helmchen camphor-derived auxiliaries


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    Oppolzer camphorsultam auxiliaries in asymmetric alkylation:

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