Addition to Carbonyl Compounds
- Page ID
- 22915
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Addition to carbonyl groups varies depending on the type of carbonyl. The following trend is observed:
Some important topics related to carbonyl addition reactions are listed below. Reactions of enolates with other carbonyl compounds can be found in the Enolates section.
Aldehydes and Ketones
Problems
Deprotonation:
Reduction:
Reduction can be avoided by the addition of Cerium(III) Chloride:
Esters
Amides
The Weinreb amide is a useful funcitonal group to synthesize ketones.