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Addition to Carbonyl Compounds

  • Page ID
    22915
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    Addition to carbonyl groups varies depending on the type of carbonyl. The following trend is observed:

    CO-reactivity.png

    Some important topics related to carbonyl addition reactions are listed below. Reactions of enolates with other carbonyl compounds can be found in the Enolates section.

    Aldehydes and Ketones

    add-ketone.png

    Problems

    Deprotonation:

    acetone-pka.png

    Reduction:

    reduction.png

    Reduction can be avoided by the addition of Cerium(III) Chloride:

    red-ex1.png

    red-ex2.png

    Esters

    add-esters.png

    Amides

    add-DMF.png

    The Weinreb amide is a useful funcitonal group to synthesize ketones.


    Addition to Carbonyl Compounds is shared under a not declared license and was authored, remixed, and/or curated by LibreTexts.

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