# Homework 8 (Due 4/25/16)

Name: ______________________________

Section: _____________________________

Student ID#:__________________________

## Q8.1

If your student colleagues argues that a catalysts affects only the rate of only one direction of a reaction. Explain why he is correct or not.

## Q8.2

The substrate N-acetylglycine ethyl ester can be catalyzed by the enzyme carbonic anhydrase. This enzyme has a turnover rate of 30,000 s-1. Determine how long it will take carbonic anhydrase to cleave the substrate.

## Q8.3

Is it appropriate to use the rapid equilibrium scheme to model the kinetics of a catalyzed reaction with the following rate constants?

$$k_1 = 7 \times 10^7\ M^{-1}\ s^{-1}$$

$$k_{-1} = 8 \times 10^5\ s^{-1}$$

$$k_2 = 5 \times 10^4\ s^{-1}$$

HInt: Compare $$K_s$$ vs. $$K_M$$ for the standard enzyme kinetics model.