Carbonyl Reduction Reactions
Aldehydes and ketones can be partially reduced to alcohols with sodium borohydride or Raney nickel. Of course, LiAlH4 could be used in stead of NaBH4. However, LiAlH4 is a stronger reducing agent so some benefits of selectivity are lost. Depending on the presence of more than one functional group within a single molecule, reaction selectivity can be useful. Aldehydes and ketones can be fully reduced to alkanes the Wolff-Kishner or Clemmensen Reduction.
Hydride Reduction Mechanism
The hydride reduction mechanism follows the pattern we have learned for other nucleophilic addition reactions.
27. Complete the reaction map below.