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4: Amino Acids, Proteins, and Enzymes

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    178775
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    • 4.1: Prelude to Amino Acids, Proteins, and Enzymes
      Insulin is a hormone that is synthesized in the pancreas. Insulin stimulates the transport of glucose into cells throughout the body and the storage of glucose as glycogen. People with diabetes do not produce insulin or use it properly. The isolation of insulin in 1921 led to the first effective treatment for these individuals.
    • 4.2: Properties of Amino Acids
      Amino acids can be classified based on the characteristics of their distinctive side chains as nonpolar, polar but uncharged, negatively charged, or positively charged. The amino acids found in proteins are L-amino acids.
    • 4.3: Reactions of Amino Acids
      Amino acids can act as both an acid and a base due to the presence of the amino and carboxyl functional groups. The pH at which a given amino acid exists in solution as a zwitterion is called the isoelectric point (pI).
    • 4.4: Peptides
      The amino group of one amino acid can react with the carboxyl group on another amino acid to form a peptide bond that links the two amino acids together. Additional amino acids can be added on through the formation of addition peptide (amide) bonds. A sequence of amino acids in a peptide or protein is written with the N-terminal amino acid first and the C-terminal amino acid at the end (writing left to right).
    • 4.5: Proteins
      Proteins can be divided into two categories: fibrous, which tend to be insoluble in water, and globular, which are more soluble in water. A protein may have up to four levels of structure. The primary structure consists of the specific amino acid sequence. The peptide chain can form an α-helix or β-pleated sheet, which is known as secondary structure and are incorporated into the tertiary structure of the folded polypeptide. The quaternary structure describes the arrangements of subunits.
    • 4.6: Enzymes
      An enzyme is a biological catalyst, a substance that increases the rate of a chemical reaction without being changed or consumed in the reaction. A systematic process is used to name and classify enzymes.
    • 4.7: Enzyme Action
      A substrate binds to a specific region on an enzyme known as the active site, where the substrate can be converted to product. The substrate binds to the enzyme primarily through hydrogen bonding and other electrostatic interactions. The induced-fit model says that an enzyme can undergo a conformational change when binding a substrate. Enzymes exhibit varying degrees of substrate specificity.
    • 4.8: Enzyme Activity
      Initially, an increase in substrate concentration increases the rate of an enzyme-catalyzed reaction. As the enzyme molecules become saturated with substrate, this increase in reaction rate levels off. The rate of an enzyme-catalyzed reaction increases with an increase in the concentration of an enzyme. At low temperatures, an increase in temperature increases the rate of an enzyme-catalyzed reaction; at higher temperatures, the protein will denature. Enzymes have optimum pH ranges.
    • 4.9: Enzyme Inhibition
      An irreversible inhibitor inactivates an enzyme by bonding covalently to a particular group at the active site. A reversible inhibitor inactivates an enzyme through noncovalent, reversible interactions. A competitive inhibitor competes with the substrate for binding at the active site of the enzyme. A noncompetitive inhibitor binds at a site distinct from the active site.
    • 4.10: Enzyme Cofactors and Vitamins
      Vitamins are organic compounds that are essential in very small amounts for the maintenance of normal metabolism. Vitamins are divided into two broad categories: fat-soluble vitamins and water-soluble vitamins. Most water-soluble vitamins are needed for the formation of coenzymes, which are organic molecules needed by some enzymes for catalytic activity.
    • 4.11: Amino Acids, Proteins, and Enzymes (Summary)
      To ensure that you understand the material in this chapter, you should review the meanings of the bold terms in the following summary and ask yourself how they relate to the topics in the chapter.
    • 4.12: Amino Acids, Proteins, and Enzymes (Exercises)
      Problems and select solutions for the chapter.


    4: Amino Acids, Proteins, and Enzymes is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.

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