# Roadmap Problems in Natural Product synthesis

Topics required for successful completion are listed under each link.

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition, Pericyclics

Carbonyl addition, Elimination, Alkene addition, Pericyclics

Carbonyl Addition, Aldol, Carboxyl Substitution, Oxidation, Nucleophilic Substitution, Elimination, Radicals

Aplykurodinone, Danishefsky, 2010

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

Aza-epothilone B, Danishefsky, 2000

Carbonyl addition, Carboxylic substitution, Nucleophilic Substitution, Bioassay study

Callipeltoside, MacMillan, 2008

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition

Carbonyl addition, Carboxylic substitution

Carbonyl addition, Carboxylic substitution, Nucleophilic substitution & elimination, Oxidation, Alkene oxidation, Pericyclics

Carbonyl addition, Carboxylic substitution, Nucleophilic Substitution

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition, Radicals

Carbonyl addition, Conjugate addition, Enolates, Carboxylic substitution, Nucleophilic substitution, Alkene addition, Rearrangements, Radicals

Glucosylceramide, Overkleeft, 2007

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

Contains a bioassay exercise.

Carbonyl addition, Carboxylic substitution, Aldol & Claisen, A-lpha-alkylation, Conjugate addition, Oxidation, Nucleophilic Substitution & Elimination

Juvenile Hormone 1, Corey, 1968

Carbonyl addition, Phosphorus ylides, Carboxylic substitution, Oxidation, Nucleophilic substitution, Cuprate addition, Alkene addition

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Alkene oxidation

Carbonyl addition, Conjugate addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

Carbonyl addition, Aldols, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Pericyclics

Perhydrohistrionicotoxin, Corey, 1975

Carbonyl addition, Enolates, Conjugate addition, Carboxylic substitution, Oxidation, Nucleophilic substitution & elimination, Radicals

Carbonyl addition, Aldols, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Pericyclics

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination

Carbonyl addition, Carboxylic substitution, Nucleophilic Substitution

Carbonyl addition, Carboxylic substitution

Carbonyl addition, Carboxylic substitution

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution, Alkene addition

Contains a bioassay exercise.

Serotobenine, Fukuyama & Kan, 2008

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Alkene oxidation, Pericyclics

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic Substitution & Elimination, Alkene oxidation

Carbonyl addition, Enolates, Conjugate addition, Carboxylic substitution, Nucleophilic substitution & elimination, Alkene oxidation

Exercise: catalytic cycles in transition metal organometallics.

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution & elimination, Alkene oxidation, Pericyclics, Radicals

Carbonyl addition, Carboxylic substitution, Aldol

Carbonyl addition, Carboxylic substitution, Oxidation, Nucleophilic substitution, Alkene addition, Alkene oxidation, Pericyclics, Rearrangements

Zaragozic acid, Nicolaou, 1994

Carbonyl addition, Carboxylic Substitution, Sulfur ylides, Oxidation, Nucleophilic substitution, Alkene oxidation, Radicals, Organo-transition metal reactions

Nucleophilic Substitution, Alkene addition