Conversion to ketones using Grignard reagents
- Page ID
- 5369
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Grignard reagents can attack the electophillic carbon in a nitrile to form an imine salt. This salt can then be hydrolyzed to become a ketone.
General Reaction
Example
Mechanism
1) Nucleophilic Attack by the Grignard Reagent
2) Protonation
3) Protonation
4) Nucleophilic attack by water
5) Proton Transfer
6) Leaving group removal
7) Deprotonation
Contributors
Prof. Steven Farmer (Sonoma State University)