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Conversion to ketones using Grignard reagents

  • Page ID
    5369
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    Grignard reagents can attack the electophillic carbon in a nitrile to form an imine salt. This salt can then be hydrolyzed to become a ketone.

    General Reaction

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    Example

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    Mechanism

    1) Nucleophilic Attack by the Grignard Reagent

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    2) Protonation

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    3) Protonation

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    4) Nucleophilic attack by water

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    5) Proton Transfer

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    6) Leaving group removal

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    7) Deprotonation

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    Contributors

    Prof. Steven Farmer (Sonoma State University)


    Conversion to ketones using Grignard reagents is shared under a CC BY-NC-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.

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