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Chemistry LibreTexts

Conversion of a Carboxylic Acid to an Amide

The direct reaction of a carboxylic acid with an amine would be expected to be difficult because the basic amine would deprotonate the carboxylic acid to form a highly unreactive carboxylate. However when the ammonium carboxylate salt is heated to a temperature above 100 oC water is driven off and an amide is formed. 

General Reaction

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Going from reactants to products simply

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Contributors

Prof. Steven Farmer (Sonoma State University)