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Acid chlorides react with ammonia, 1° amines and 2° amines to form amides

  • Page ID
    5956
  • Acid chlorides react with ammonia, 1o amines and 2o amines to form amides.

    General Reaction

    Examples:

    Mechanism

    1) Nucleophilic attack by the amine

    2) Leaving group is removed

    3) Deprotonation

    Contributors

    Prof. Steven Farmer (Sonoma State University)