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3.6E: Mixed Solvent Summary

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    Table 3.5: Procedural summary for mixed solvent crystallization.
    Find a miscible pair of solvents: one in which the desired compound is soluble (called the "soluble solvent") and one in which the compound is insoluble (called the "insoluble solvent").

    Place the impure solid in an Erlemeyer flask along with a boiling stick (or boiling stones if preferred).

    Add the soluble solvent in portions while heating until the solvent just dissolves.

    Allow time in between additions, and allow each addition to come completely to a boil before adding more.

    Add the insoluble solvent in portions with heating until the solution becomes faintly cloudy. Add the "soluble solvent" dropwise with heating until the solution is clarified (transparent).
    Remove the boiling stick (if used) and allow the system to come to room temperature while sitting atop some paper towels and with the flask's mouth covered by a watch glass.

    Scratch with a glass stirring rod to initiate crystallization if necessary.

    Submerge in an ice bath for 10-20 minutes.

    Collect the crystals by suction filtration.

    This page titled 3.6E: Mixed Solvent Summary is shared under a CC BY-NC-ND 4.0 license and was authored, remixed, and/or curated by Lisa Nichols via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request.

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