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19.6: Nucleophilic Addition of HCN- Cyanohydrin Formation

  • Page ID
    36386
  • Objectives

    After completing this section, you should be able to

    1. write an equation to describe the formation of a cyanohydrin from an aldehyde or ketone.
    2. identify the cyanohydrin formed from the reaction of a given aldehyde or ketone with hydrogen cyanide.
    3. identify the aldehyde or ketone, the reagents, or both, needed to prepare a given cyanohydrin.
    4. write the detailed mechanism for the addition of hydrogen cyanide to an aldehyde or ketone.
    Key Terms

    Make certain that you can define, and use in context, the key term below.

    • cyanohydrin
    Study Notes

    For successful cyanohydrin formation it is important to have free cyanide ions available to react with the ketone or aldehyde. This can be achieved by using a salt (e.g. KCN or NaCN) or a silylated (e.g. Me3SiCN) form of cyanide under acidic conditions or by using HCN with some base added to produce the needed CN nucleophile.

    Hydrogen cyanide (HC≡N), adds reversibly to aldehydes and many ketones forming hydroxyalkanenitrile adducts commonly known and as cyanohydrins. Cyanohydrins have the structural formula of R2C(OH)CN. The “R” on the formula represents an alkyl group, aryl group, or hydrogen.

    General Reaction of Cyanohydrin Formation.svg

    Figure \(\PageIndex{1}\): General Reaction of Cyanohydrin Formation

    An important feature of cyanohydrin formation is that it requires a basic catalyst. Since hydrogen cyanide itself is a weak acid (pKa = 9.25), the best results occur when a small amount of a strong base activates hydrogen cyanide by converting it to cyanide ion (-C≡N), which can function as a carbon nucleophile. In the absence of base, the reaction does not proceed, or is at best very slow. Cyanohydrin formation is weakly exothermic, and is favored for aldehydes, and unhindered cyclic and methyl ketones.

    Example

    examples of cyanohydrin formation; cyclohexanone reacts with HCN to give 1-hydroxycyclohexane-1-carbonitrile and reaction of formaldehyde with HCN to give 2-hydroxy-2-phenylacetonitrile.svg

    Hydrogen cyanide (HCN) is hazardous to handle because it is highly toxic. Therefore in many syntheses of cyanohydrins, HCN is created in situ by adding a strong acid to a mixture of sodium cyanide and the carbonyl compound, so that hydrogen cyanide is generated in situ. The amount of acid added should be insufficient to consume all the cyanide ion, therefore sufficiently alkaline conditions are maintained for rapid addition.

    Mechanism of Cyanohydrin Formation

    In the first step of the mechanism, the cyanide ion acts as a nucleophile and forms a C-C bond with the electrophillic carbonyl carbon. The two electrons in the carbonyl pi bond are pushed on to the electronegative oxygen forming a tetrahedral alkoxide ion intermediate. In the second step, the alkoxide ion is protonated by HCN which regenerates the cyanide ion.

    Step 1: Nucleophilic attack

    cyanohydrin formation mechanism step 1.svg

    Step 2: Protonation

    cyanohydrin formation mechanism step 2.svg

    Further Chemistry of Cyanohydrins

    Cyanohydrin functional groups often prove useful because of the further chemistry that can be carried out due to the presence of a hydroxyl and a nitrile functionality. In particular, dehydration can convert the hydroxyl group into an alkene (Section 17.6). The nitrile can be converted into a carboxylic acid function group through reaction with a hot acidic aqueous solution (Section 20.7). Also, the nitrile can be reduced by the addition of LiAlH4 to form a primary amine.

    dehydration of 2-hydroxy-2-methylpropanenitrile to give 2-methylpropenenitrile, reaction of 2-hydroxy-2-methylpropanenitrile with aqueous acid to give 2-hydroxy-2-methylpropanoic acid.svg
     

    reduction of 2-hydroxy-2-methylpropanenitrile with LiAlH4, followed by acid quench to give 1-amino-2-methylpropan-2-ol.svg

    Other Cyanohydrins

    Other interesting cyanohydrins are: acetone cyanohydrin, and glycolonitrile.

    skeletal structures of acetone cyanohydrin and glycolonitrile.svg

    Acetone cyanohydrin has the structure, (CH3)2C(OH)CN, and is used in the production of methyl methacrylate (also known as acrylic). Glycolonitrile is an organic compound with the structural formula of HOCH2CN, which is the simplest cyanohydrin that is derived by formaldehydes.

    Problems

    Complete the following reactions for cyanohydrins:

    1)

    Problem 1 structure.svg

    2)

    Problem 2 structures.svg

    3) True or False: For a cyanohydrin to form, a fast addition of strong acid to cyanide salt is carried out to convert the salt into HCN.

    4) True or False: Cyanohydrin reactions are irreversible.

    5) What is the product for the overall reaction?

    Question 5 Structures.svg

    Answers

    1)

    answer 1 structure.svg

    2)

    problem2a.jpg

    3) False, slow addition

    4) False, reversible

    5)

    Answer 5 structure.svg

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