The acetoacetic ester synthesis allows for the conversion of ethyl acetoacetate into a methyl ketone with one or two alkyl groups on the alpha carbon.
1) Deprotonation with ethoxide
2) Alkylation via and SN2 Reaction
3) Hydrolysis and decarboxylation
Addition of a second alky group
After the first step and additional alkyl group can be added prior to the decarboxylation step. Overall this allows for the addition of two different alkyl groups.
Prof. Steven Farmer (Sonoma State University)