Isoprenoid biosynthesis
- Page ID
- 948
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Sections/problems listed with an asterisk (*) do not discuss the exact reaction indicated, but do discuss a closely related reaction.
Synthesis of isopentenyl diphosphate building blocks
Mevalonate pathway
- Acetoacetyl CoA acetyltransferase (EC 2.3.1.9) Section 13.4A
- 3-hydroxy-3-methylglutaryl-CoA synthase (EC 2.3.3.10) P13.1
- HMG-CoA reductase (EC 1.1.1.34) Section 16.4D
- Mevalonate kinase (EC 2.7.1.36) Section 10.2C
- Phosphomevalonate kinase (EC 2.7.4.2) Section 10.2C
- Mevalonate diphosphate decarboxylase (EC 4.1.1.33) Section 14.3B
Deoxyxylulose phosphate pathway (bacteria, plant plastids)
- Deoxyxylulose phosphate synthase (EC 2.2.1.7) Section 14.5*; P14.5b
- Deoxyxylulose phosphate reductoisomerase (EC 1.1.1.267) P15.16
- MEP cytidylyltransferase (EC 2.7.7.60) Section 10.2E
- CDP-ME kinase (EC 2.7.1.148) Section 10.2E
- Methylerithritol 2,4-cyclodiphosphate synthase (EC 4.6.1.12) Section 10.2E
Chain elongation and prenyl transfer
- Isopentenyl diphosphate isomerase (EC 5.3.3.2) Section 15.3A
- Geranyl diphosphate synthase (EC 2.5.1.1) Section 15.3B
- Farnesyl diphosphate synthase (EC 2.5.1.10) Section 15.3B
- Squalene synthase (EC 2.5.1.21) Section 15.9, Section 16.6A
- Oxidosqualene cyclase (EC 5.4.99.7) Section 15.7B
- DMAPP-tryptophan synthase (EC 2.5.1.34) Section 15.5B
- protein prenyltransferase (EC 2.5.1.58) Section 9.3